ABSTRACT
The last 2 years has been highly tumultuous with the advent of the 2019 novel coronavirus disease (nCovid-19). This viral infection has been a global landmark event in the history of mankind with its standout characteristics such as high transmission rate, initial asymptomatic period, and unexpected systemic outcomes. The long-term damage of this disease is still being unraveled with a profound impact on the global economy and livelihood of millions as well. A literature search was performed with the following keywords - Coronavirus, COVID-19, SARS-CoV-2, 2019-nCoV, Mucormycosis, and Opportunistic infections - in PUBMED/MEDLINE database to assimilate articles/case reports/books about nCovid19 and mucormycosis. nCovid19 data were collected from the Centers for Disease Control and Prevention and Ministry of Health and Family Welfare websites also. This review describes the etiopathogenesis of nCovid19, including the mutation and origin of variants seen so far. We recapitulate existing knowledge of clinical features, investigations, and treatment strategies followed. The various complications seen in nCovid19 recovery patients are also elaborated with a focus on the alarming surge of mucormycosis and mortality in post-nCovid19-affected persons. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
ABSTRACT
Background: Vaccination is essential and advised to prevent the spread of the pandemic COVID-19. There has been a difference of intention to take vaccination among people with a fear from the various misinformation. Methods: Studies with a national representative samples of size greater than thousand were considered for the study meta-analysis was conducted among those anticipating to get vaccinated, unsure, or planning to refuse a COVID-19 vaccine when available were considered for the study. Generic inverse meta-analysis and meta-regression were used to group estimates and examine time trends. Scopus, PubMed were searched from May-November, 2020. Findings: 25nationally representative samples from various continents indicate that there has been a increase in those who intend not to get vaccinated as the pandemic progressed. Though not significant there were noted changes when the following groups were considered educated vs illiterate, higher vs low economic conditions, healthy vs comorbidities, developed vs developing nations and cultures. Interpretation: Goals to take COVID-19 vaccination if it is available are seen diminishing universally and hence a need to address social imbalances in vaccination diffidence is needed and endorse extensive take-up of vaccination as they become accessible.